Poly(ethylene glycol) 600 CAS NO.25322-68-3

Product Name: PEG 400

Polyethylene glycol 400
Poly(ethylene glycol))
CAS: 25322-68-3
Chemical formula: N/A

Appearance
This product is white granular. Soluble in water, soluble in some organic solvents. The solution has high viscosity at low concentration, and can be processed by rolling, extrusion, casting, etc. It is a thermoplastic resin with good compatibility with other resins. It is resistant to bacterial attack and has weak hygroscopicity in the atmosphere.

Preparation
Ethylene oxide is prepared by autopolymerization of aluminum isopropyl alcohol.

Use
Polyoxyethylene resin is a high molecular weight homopolymer prepared by polyphase catalytic ring-opening polymerization of ethylene oxide. It can usually be distinguished into relative molecular mass of more than 2× 104 and tens of thousands of more, the former is called polyethylene glycol, the latter is called polyoxide ethylene. Polyoxide ethylene has flocculation, thickening, slow release, lubrication, dispersion, retention, water retention and other properties, suitable for medicine, fertilizer, paper, ceramics, detergents, cosmetics, heat treatment, water treatment, fire protection, oil mining and other industries, the product is non-toxic and non-irritating, will not remain in the product production process, deposition or breeding volatiles. As a papermaking additive, it can improve the retention rate of fillers and fine fibers, and is especially suitable for long fibers as a dispersant, which can shorten the beating time.

Security
It has little irritation to the skin and eyes, is difficult to be absorbed by the gastrointestinal tract when taken orally, and has very low toxicity. An aqueous solution of 5% (by mass) polyoxyethylene injected into the rabbit's eyes caused only minor burning. Polyoxyethylene had little effect on the death rate of fish, crabs, anemones, shrimp or algae. Its resin and aqueous solution are low toxic and very safe to use and handle. The U.S. Food and Drug Administration (FDA) has approved polyoxyethylene aqueous solution resins for use in specialized food packaging and as direct additives to beer.

 

Test Items	Analytical method	Standard
Appearance ( 2 5 ℃ )	Current EP	Clear, viscous, colourless or almost colourless, hygroscopic liquid
Identification	Current EP	A
	Current EP	B
	Current EP	C
Appearance of  solution	Current EP	Meet requirements
Completeness and Color of Solution	Current USP	Meet requirements
Acidity or alkalinity	Current EP	Meet requirements
Acidity and Alkalinity	Current USP	4.5-7.5
Average Molecular Weight	Current USP	380-420
Viscosity( 20℃ ，mPa·s)	Current EP	105-130
Viscosity( 98 .9℃ ，cst)	Current USP	6.8-8.0
Hydroxyl value	Current EP	264-300
Reducing substances	Current EP	Meet requirements
Ethylene Glycol and Diethylene Glycol (%)	Current USP	≤0.25
Ethylene Glycol and Diethylene Glycol (%)	Current EP	≤0.4
Formaldehyde (ppm)	Current EP	≤15
Ethylene oxide (ppm)	Current EP	≤1
Dioxan( ppm)	Current EP	≤10
Free Ethylene Oxide( μ g/ g) 1 ,4-Dioxane( μg/g)	Current USP Current USP	≤10 ≤10
Water (%)	Current EP	≤2.0
Sulfated ash(% )	Current EP	≤0.2
Residue on Ignition (%)	Current USP	≤0. 1
Heavy Metals ( ppm)	Current USP	≤5

 

Safety Data Sheet

1.Identification of the substance/preparation and of the company/undertaking

2.Composition/information on ingredient

Product Name:Polyethylene glycol 400

Material Number: 106

CAS Number:25322-68-3

Synonyms:Products has no synonyms

Primacy product use:Pharma

Chemical family:Polyethylene glycol,HO-(CH2-CH2-O)n-H,average molecular mass 400

Identified uses

A partial list of examples include pharmaceutical products, personal care products, automotive

products, household products, packaging products, petroleum chemicals, plastics, inks, coatings,

adhesives, chemical intermediates, rubber processing, lubricants, metalworking fluids, mold release

agents, ceramics, and wood treating. CAUTION! For food, feed, drug or cosmetic applications.

Component Polyethylene glycol

Amount ≥99.0 %

Classification: Not classified.

CAS # 25322-68-3

EC # Polymer

Product Name: PEG 400

3. Hazards Identification

Emergency overview; Cololess liquid

Expect routine of Entry:

Inhalation: particulates of this material are probably irritating to

Resparitory passages nose and throat.

Skin contact: may cause mild skin irritation

Eye contact: may cause mild eye irritaiton

Ingestion:Not expected to be toxic

Skin aborptio : No

Health effect of exposure:

Particular not otherwise regulated(PNOR)

Although this substance did not cause irritation in standard skin and eye irritationas per

studies,particulates of this material may cause mechanical irritaiton to the skin eyes or

respiratory tract

4. First-aid measures

Description of first aid measures

General advice: If potential for exposure exists refer to Section 8 for specific personal protective

equipment.

Inhalation: Move person to fresh air; if effects occur, consult a physician.

Skin Contact: Wash skin with plenty of water.

Eye Contact: Flush eyes thoroughly with water for several minutes. Remove contact lenses after the

initial 1-2 minutes and continue flushing for several additional minutes. If effects occur, consult a

physician, preferably an ophthalmologist.

Ingestion: No emergency medical treatment necessary.

Most important symptoms and effects, both acute and delayed

Aside from the information found under Description of first aid measures (above) and Indication of

immediate medical attention and special treatment needed (below), no additional symptoms and

effects are anticipated.

Indication of immediate medical attention and special treatment needed

Absorption may be promoted by damaged skin. J Pharm Sci. 1985 Oct;74(10):1062-6; Burns Incl

Therm Inj 1982 Sep;9(1):49-52. No specific antidote. Treatment of exposure should be directed at the

control of symptoms and the clinical condition of the patient.

5. Fire Fighting Measures

Suitable extinguishing media

Water fog or fine spray. Dry chemical fire extinguishers. Carbon dioxide fire extinguishers. Foam.

Alcohol resistant foams (ATC type) are preferred. General purpose synthetic foams (including AFFF)

or protein foams may function, but will be less effective.

Extinguishing Media to Avoid: Do not use direct water stream. May spread fire.

Special hazards arising from the substance or mixture

Hazardous Combustion Products: During a fire, smoke may contain the original material in addition

to combustion products of varying composition which may be toxic and/or irritating. Combustion

products may include and are not limited to: Carbon monoxide. Carbon dioxide.

Unusual Fire and Explosion Hazards: Container may rupture from gas generation in a fire situation.

Violent steam generation or eruption may occur upon application of direct water stream to hot liquids.

Advice for firefighters

Fire Fighting Procedures: Keep people away. Isolate fire and deny unnecessary entry. Use waterProduct Name: PEG 400

spray to cool fire exposed containers and fire affected zone until fire is out and danger of reignition has

passed. Fight fire from protected location or safe distance. Consider the use of unmanned hose

holders or monitor nozzles. Immediately withdraw all personnel from the area in case of rising sound

from venting safety device or discoloration of the container. Do not use direct water stream. May

spread fire. Move container from fire area if this is possible without hazard. Burning liquids may be

moved by flushing with water to protect personnel and minimize property damage.

Special Protective Equipment for Firefighters: Wear positive-pressure self-contained breathing

apparatus (SCBA) and protective fire fighting clothing (includes fire fighting helmet, coat, trousers,Product Name: PEG 400

boots, and gloves). If protective equipment is not available or not used, fight fire from a protected

location or safe distance.

6. Accidental Release Measures

Personal precautions, protective equipment and emergency procedures: Use appropriate safety

equipment. For additional information, refer to Section 8, Exposure Controls and Personal Protection.

Environmental precautions: Prevent from entering into soil, ditches, sewers, waterways and/or

groundwater. See Section 12, Ecological Information.

Methods and materials for containment and cleaning up: Contain spilled material if possible.

Collect in suitable and properly labeled containers. See Section 13, Disposal Considerations, for

additional information.

7. Handling and Storage

Handling

General Handling: See Section 8, EXPOSURE CONTROLS AND PERSONAL PROTECTION.

Other Precautions: Spills of these organic materials on hot fibrous insulations may lead to lowering of

the autoignition temperatures possibly resulting in spontaneous combustion.

Storage

Store in original container. Use product promptly after opening. Avoid prolonged exposure to heat

and air. Store in the following material(s): Stainless steel. Polypropylene. Polyethylene-lined

container. Teflon. Glass-lined container. Plasite 3066 lined container. Plasite 3070 lined container.

316 stainless steel.

8. Exposure Controls / Personal Protection

Exposure Limits

Component

List

Type

Value

Polyethylene glycol

AIHA WEEL

TWA

Particulate.

10 mg/m3

Personal Protection

Eye/Face Protection: Use safety glasses (with side shields). Safety glasses (with side shields)

should be consistent with EN 166 or equivalent.

Skin Protection: When prolonged or frequently repeated contact could occur, use protective clothing

chemically resistant to this material. Selection of specific items such as faceshield, boots, apron, or

full-body suit will depend on the task.

Hand protection: Use gloves chemically resistant to this material when prolonged or

frequently repeated contact could occur. Use chemical resistant gloves classified under

Standard EN374: Protective gloves against chemicals and micro-organisms. Examples of

preferred glove barrier materials include: Butyl rubber. Ethyl vinyl alcohol laminate ("EVAL").

Examples of acceptable glove barrier materials include: Natural rubber ("latex"). Neoprene.

Nitrile/butadiene rubber ("nitrile" or "NBR"). Polyvinyl chloride ("PVC" or "vinyl"). Viton. When

prolonged or frequently repeated contact may occur, a glove with a protection class of 4 or

higher (breakthrough time greater than 120 minutes according to EN 374) is recommended.

When only brief contact is expected, a glove with a protection class of 1 or higher

(breakthrough time greater than 10 minutes according to EN 374) is recommended. NOTICE:Product Name: PEG 400

The selection of a specific glove for a particular application and duration of use in a workplace

should also take into account all relevant workplace factors such as, but not limited to: Other

chemicals which may be handled, physical requirements (cut/puncture protection, dexterity,

thermal protection), potential body reactions to glove materials, as well as the

instructions/specifications provided by the glove supplier.

Respiratory Protection: Respiratory protection should be worn when there is a potential to exceed

the exposure limit requirements or guidelines. If there are no applicable exposure limit requirements

or guidelines, wear respiratory protection when adverse effects, such as respiratory irritation or

discomfort have been experienced, or where indicated by your risk assessment process. For most

conditions no respiratory protection should be needed; however, if discomfort is experienced, use an

approved air-purifying respirator. Use the following CE approved air-purifying respirator: Organic

vapor cartridge with a particulate pre-filter, type AP2.

Ingestion: Use good personal hygiene. Do not consume or store food in the work area. Wash hands

before smoking or eating.

Engineering Controls

Ventilation: Use local exhaust ventilation, or other engineering controls to maintain airborne levels

below exposure limit requirements or guidelines. If there are no applicable exposure limit

requirements or guidelines, general ventilation should be sufficient for most operations. Local exhaust

ventilation may be necessary for some operations.

9. Physical and Chemical Properties

Appearance

Physical State

Colorless viscous liquid

Color

Odor

Odor Threshold

pH

Viscosity(mm2/s)

Freezing Point

Boiling Point (760 mmHg)

Flash Point - Closed Cup

Flash Point - Open Cup

Evaporation Rate (Butyl

Acetate = 1)

Flammability (solid, gas)

Flammable Limits In Air

Colorless

Mild

No test data available

4.5 – 7.5 ASTM E70 (5% aqueous solution)

6.8-8.0

50 - 54 °C

> 200 °C Calculated Decomposes.

229 °C ASTM D93

291 °C ASTM D92

No test data available

Not applicable to liquids

Lower: No test data available

Upper: No test data available

10. Stability and Reactivity

Reactivity

No dangerous reaction known under conditions of normal use.

Chemical stability

Thermally stable at typical use temperatures.

Possibility of hazardous reactions

Polymerization will not occur.Product Name: PEG 400

Conditions to Avoid: Exposure to elevated temperatures can cause product to decompose.

Generation of gas during decomposition can cause pressure in closed systems.

Incompatible Materials: Avoid contact with: Strong acids. Strong bases. Strong oxidizers.

Hazardous decomposition products

Decomposition products depend upon temperature, air supply and the presence of other materials.

Decomposition products can include and are not limited to: Aldehydes. Alcohols. Ethers. Carbon

dioxide. Carboxylic acids. Polymer fragments.

11. Toxicological Information

Acute Toxicity

Ingestion

Very low toxicity if swallowed. Harmful effects not anticipated from swallowing small amounts.

LD50, Rat > 10,000 mg/kg

Aspiration hazard

Based on physical properties, not likely to be an aspiration hazard.

Dermal

Prolonged skin contact is unlikely to result in absorption of harmful amounts. Prolonged/repeated

exposure to damaged skin (as in burn patients) may result in absorption of toxic amounts.

LD50, Rabbit > 20,000 mg/kg

Inhalation

At room temperature, exposure to vapor is minimal due to low volatility; single exposure is not likely to

be hazardous. For respiratory irritation and narcotic effects: No relevant data found.

Typical for this family of materials. No deaths occurred at this concentration. LC50, 6 h, Aerosol, Rat

> 2.5 mg/l

Eye damage/eye irritation

May cause slight temporary eye irritation. Corneal injury is unlikely.

Skin corrosion/irritation

Prolonged contact may cause slight skin irritation with local redness.

Sensitization

Skin

For this family of materials: Did not cause allergic skin reactions when tested in humans. For this

family of materials, sensitization studies done in guinea pigs have been negative.

Respiratory

No relevant data found.

Repeated Dose Toxicity

Recent findings of kidney failure and death in burn patients, as well as some studies using animal burn

models, suggest that polyethylene glycol may have been a factor. The use of topical applications

containing this material may not be appropriate in severely burned patients or individuals with impaired

renal function. Based on available data, repeated exposures are not anticipated to cause significant

adverse effects.

Chronic Toxicity and Carcinogenicity

Similar material(s) did not cause cancer in laboratory animals.

Developmental Toxicity

For similar material(s): Did not cause birth defects in laboratory animals.

Reproductive Toxicity

For similar material(s): In animal studies, did not interfere with reproduction.Product Name: PEG 400

Biodegradation

Exposure Time

Method

10 Day Window

90 %

28 d

OECD 301F Test

pass

55 %

28 d

OECD 306 Test

Not applicable

Genetic Toxicology

For similar material(s): In vitro genetic toxicity studies were negative. Animal genetic toxicity studies

were negative.

12. Ecological Information

Toxicity

Material is not classified as dangerous to aquatic organisms (LC50/EC50/IC50/LL50/EL50 greater than

100 mg/L in most sensitive species).

Fish Acute & Prolonged Toxicity

LC50, fathead minnow (Pimephales promelas), 96 h: > 10,000 mg/l

Aquatic Invertebrate Acute Toxicity

LC50, water flea Daphnia magna, 48 h: > 10,000 mg/l

Aquatic Plant Toxicity

EbC50, diatom Skeletonema costatum, biomass growth inhibition, 3 d: 14,853 mg/l

Persistence and Degradability

Material is readily biodegradable. Passes OECD test(s) for ready biodegradability.

OECD Biodegradation Tests:

Bioaccumulative potential

Bioaccumulation: Bioconcentration potential is low (BCF < 100 or Log Pow < 3).

Partition coefficient, n-octanol/water (log Pow): < 2.25 Estimated.

Mobility in soil

Mobility in soil: No data available.

13. Disposal Considerations

Any disposal practice must be in compliance with all local and national laws and regulations. Do not

dump into any sewers, on the ground, or into any body of water.

14. Transport Information

ROAD & RAIL

NOT REGULATED

OCEAN

NOT REGULATED

AIR

NOT REGULATED

INLAND WATERWAYS

NOT REGULATEDProduct Name: PEG 400

This information is not intended to convey all specific regulatory or operational

requirements/information relating to this product. Additional transportation system information can be

obtained through an authorized sales or customer service representative. It is the responsibility of the

transporting organization to follow all applicable laws, regulations and rules relating to the

transportation of the material.

15. Regulatory Information

US. Toxic Substances Control Act

All components of this product are on the TSCA Inventory or are exempt from TSCA Inventory

requirements under 40 CFR 720.30

European Inventory of Existing Commercial Chemical Substances (EINECS)

This product is a polymer according to the definition in Directive 92/32/EEC (7th Amendment to

Directive 67/548/EEC) and all of its starting materials and intentional additives are listed in the

European Inventory of Existing Commercial Chemical Substances (EINECS) or in compliance with

European (EU) chemical inventory requirements.

Classification and User Label Information

This product is not classified as dangerous according to EC criteria.

16. Other Information

Product Literature

Additional information on this product may be obtained by calling your sales or customer service

contact. Ask for a product brochure. Additional information on this and other products may be

obtained by visiting our web page.

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